Stiff Person Syndrome is a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase, the key enzyme in γ -aminobutyric acid synthesis. In order to investigate the role of cerebral benzodiazepinereceptor binding in SPS, we performed [ 11 C]flumazenil positron emission tomography in a female patient with SPS compared to nine healthy controls. FMZ is a radioligand to the postsynaptic central benzodiazepine receptor which is co-localized with the GABA-A receptor. In the SPS patient, we found a global reduction of (...) cortical FMZ binding. In addition, distinct local clusters of reduced radiotracer binding were observed. These data provide first in vivo evidence for a reduced postsynaptic GABA-A receptor availability which may reflect the loss of GABAergic neuronal inhibition in SPS. (shrink)

BackgroundPrenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder. In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline was associated with improved performance on a hippocampal-dependent recognition memory task. The current paper describes the neurophysiological correlates of that memory performance for trial completers.MethodsChildren with FASD who were enrolled in a clinical trial of choline supplementation were followed for 9 months. Delayed (...) recall on a 9-step elicited imitation task served as the behavioral measure of recognition memory. Neurophysiological correlates of memory were assessed via event-related potentials.ResultsDelayed recall on EI was correlated with two ERP components commonly associated with recognition memory in young children: middle latency negative component and positive slow wave. No significant ERP differences were observed between the choline and placebo groups at the conclusion of the trial.ConclusionAlthough the small sample size limits the ability to draw clear conclusions about the treatment effect of choline on ERP, the results suggest a relationship between memory performance and underlying neurophysiological status in FASD. This trial was registered.1. (shrink)

Long awaited by the scholarly community, Wittgenstein's so-called _Big Typescript_ is presented here in an en face English–German scholar’s edition. Presents scholar’s edition of important material from 1933, Wittgenstein’s first efforts to set out his new thoughts after the publication of the _Tractatus Logico Philosophicus_ Includes indications to help the reader identify Wittgenstein’s numerous corrections, additions, deletions, alternative words and phrasings, suggestions for moves within the text, and marginal comments.

Overdose deaths involving prescription opioids killed more than 17,000 Americans in 2017, marking a five-fold increase since 1999. High prescribing rates of opioid analgesics have been a substantial contributor to prescription opioid misuse, dependence, overdose and heroin use. There was recognition approximately ten years ago that opioid prescribing patterns were contributing to this startling increase in negative opioid-related outcomes, and federal actions, including Medicare reimbursement reform and regulatory actions, were initiated to restrict opioid prescribing. The current manuscript is a description (...) of those actions, the effect of those actions on opioid prescribing and related patient outcomes. We also describe our proposal of methods of expanding these efforts as an important piece to further reduce opioid-related misuse, dependence, and overdose death. (shrink)

COVID-19 severity and mortality risk are greater for older adults whereas economic impact is deeper for younger adults. Using the Health Belief Model as a framework, this study used a web-based survey to examine how perceived COVID-19 susceptibility and severity and perceived efficacy of recommended health behaviors varied by age group and were related to the adoption of health behaviors. Proportional odds logistic regression was used to examine the relationship between age group and perceived COVID-19 susceptibility, severity, impact, and health (...) behavior efficacy and adoption. Structural equation modeling based on HBM constructs examined the relationships between health beliefs and behaviors. Data from 820 participants were analyzed. Middle-aged and older adults reported greater concerns about the personal risk of hospitalization and mortality, economic impact, and social impact of COVID-19 than young adults. Middle-aged adults also reported greatest concern for other age groups. Adoption and perceived efficacy of health behaviors was similar across age groups with few exceptions. Both middle-aged and older-adults were more likely to perceive their own and each other's age groups as responding adequately to COVID-19 compared to young adults. Structural equation modeling indicated perceived benefits of health behaviors were the primary driver of behavior uptake, with socioeconomic factors and perceived severity and susceptibility indirectly associated with uptake through their influence on perceived benefits. Overall, these results suggest adoption of health behaviors is very high with few differences between age groups, despite differences in perceived impact of COVID-19. Public health communications should focus on the benefits of health behaviors to drive adoption. (shrink)

Schon 1926 prägte der protestantische Theologe Fritz Jahr (1895-1953) aus Halle (Saale) den Begriff Bioethik. Der von Jahr vorgeschlagene bioethische Imperativ lautet dabei: «Achte jedes Lebewesen grundsätzlich als einen Selbstzweck und behandle es nach Möglichkeit als solchen!» Dieser Band untersucht die Perspektiven von Jahrs Thesen.

We outline some ways in which motor neglect (the underutilization of a limb despite adequate strength) and hysterical paralysis (failure to move a limb despite no relevant structural damage or disease) may throw light on the pathophysiology of catatonia. We also comment on the manifold inadequacies of distinguishing too firmly between symptoms of “neurologic origin” and of “psychiatric origin.”.

Wynn's claims are, in principle, entirely reasonable; although, as always, the devil is in the details. With respect to Wynn's discussion of the cultural evolution of artifactual symmetry, we provide a few more arguments for the utility of mirror symmetry and extend the enquiry into the tacit and explicit processing of natural and artifactual symmetry.

This bilingual volume—English and German on facing pages—brings together the writings Wittgenstein composed during his stay in Dublin between October 1948 and March 1949, one of his most fruitful periods. He later drew more than half of his remarks for Part II of Philosophical Investigations from this Dublin manuscript. A direct continuation of the writing that makes up the two volumes of Remarks on the Philosophy of Psychology, this collection offers scholars a glimpse of Wittgenstein's preliminary thinking on one of (...) his most important works. G. H. von Wright and Heikki Nyman both teach at the University of Helsinki. (shrink)

This article examines the role of taste perception in Galen’s research on simple drugs in relation to the acquisition of knowledge. To this end, 1.) I make it plausible through an examination of sources that the sometimes increased, more detailed and divergent indications of taste compared to his predecessors, especially Dioscorides and Sextius Niger, are based on Galen’s own research, 2.) reconstruct Galen’s research practice and 3.) examine the presentation of his results in linguistic and logical terms and explain the (...) differences to traditional pharmacology. I argue that a) gustatory perception has a special significance in Galen’s work that goes far beyond its traditional descriptive function and b) that, starting from the realisation that taste and drug action are interrelated, he assigns to taste qualities an indicator function for a much more fundamental principle that causes drug action and thus c) has prepared the ground for a pharmacognosy that also classifies according to taste principles, which was to reach its climax much later. With a view to a practice of gustatory testing of herbal drugs that is still practised today in pharmacy, which, like any other natural science discipline, has otherwise largely lost the sensory reference to its subject matter, the article would therefore like to provide an encouragement to study the “history of pharmaceutical-medical tasting”. (shrink)

In this paper I argue that there is textual evidence that the chapter on Teleology in Hegel's Science of Logic, read under certain premises, also discusses something that in contemporary analytic philosophy is called a ‘basic action’. The three moments of Teleology—(a) ‘The Subjective Purpose’, (b) ‘The Means’ and (c) ‘The Realized Purpose’—can be interpreted as (a) a certain intentional content in the mind of a subject, which can be expressed in the form of an imperative, (b) the immediate taking (...) in possession of the body, which can be described as a basic action, and (c) the description of the relation of the event brought about by the basic action with other events in the world, which can be described in the terms of event-causality. This reading reveals an astonishing parallel to Donald Davidson's distinction between proper basic actions and their different descriptions in the form of events. In this way we can make Hegel's, at first glance, confusing identification of subjective purpose (intention), means (basic action) and realized purpose (event) comprehensible. Through that, the actual aim is to show that what I call basic actions are in fact an example of a more general thought that Hegel calls a teleological relation. (shrink)

The central claim of this book is that I is a deictic term, like the other singular personal pronouns You and He/She. This is true of the logical character, inferential role, referential function, expressive use, and communicative role of all and only expressions used to formulate first-personal reference in any language. The first part of the book shows why the standard account of I as a ‘pure indexical’ (‘purism’) should be rejected. Purism requires three mutually supportive doctrines which turn out (...) to be myths: a) that a simple rule is sufficient to give the meaning of I (‘rule theory’); b) that one can use I to express thoughts without having to identify what is being referred to (‘independence’); and c) that as a matter of the meaning of I, any use of the term is logically guaranteed against failure to refer (‘the guarantee’). The second part of the book shows why the radically new account of I should be endorsed as a deictic term. Substitution instances and the behaviour of I in inference reveal that it has an obligatorily deictic logical character and inferential role. I fulfils its referential function in the deictic way, providing determinacy of reference by making an individual referentially salient in the extra-sentential context. The discriminability of the referent of an I-use depends on recognizing the referentially salient individual. This is true of its discriminability both to the reference-maker and to the audience. So I has the expressive use and communicative role of a deictic term. The conclusion of the book directs research towards the next step, showing how the meaning of I may be used to elucidate the thoughts expressed by the term, and from there questions relating to self-knowledge, practical reasoning, belief-acquisition, and belief-ascription. (shrink)

ABSTRACTIn the present study, attentional bias was investigated as a potential predisposing mechanism for the contamination-related subtype of obsessive-compulsive disorder. Fifty healthy participants with varying degrees of subclinical C-OC symptoms performed a visual search task to measure differential attentional biases elicited by neutral, disgust-, and fear-specific pictorial material. Participants had to find a target picture within five neutral distractor pictures randomly presented on different locations in an array. The task was to decide whether the array contained an unpleasant target picture (...) or not. In randomly-selected emotional trials, participants were further asked about the content of the picture and the confidence of their answer. The results show that the reaction times significantly differed between the emotional and neutral pictures. Participants were significantly more confident in answering questions referring to fear compared to disgust pictures. This effect was mar... (shrink)

Otto Pöggeler is among the most distinguished living German scholars. He is the coeditor of the new critical edition of the works of Hegel published by the Deutsche Forschungsgemeinschaft. In addition he is the author of what many regard as the book on Heidegger. He has access to documents that Heidegger makes available to only a few and is considered to have an acquaintance with the pre-Sein und Zeit period that is matched by none. This latest volume--a collection of important (...) articles that have appeared in European periodicals on Heidegger, and offered on the occasion of his 80th birthday--is exactly what one would expect of Pöggeler. The contributions are most distinguished. To name a few: Löwith on Heidegger and Protestant theology; Schulz's famous article on the place of Heidegger in the history of Philosophy; Gadamer on Heidegger and Marburg theology; Beda Allemann on Heidegger's engagement with the National Socialists; Tugendhat on Heidegger's idea of truth; and finally an article by Pöggeler on Heidegger's hermeneutics. Pöggeler also provides a 38-page introduction entitled "Heidegger Today." In addition to a helpful index, there is a tripartite bibliography including not only Heidegger's works and the important secondary literature but also the works of independent thinkers who think out of the context and under the influence of Heidegger--such as Binswanger, Bultmann, Fink, Löwith et al.--J. D. C. (shrink)

This volume contains the minutes of a seminar which was held on Heraclitus in the University of Freiburg under the joint direction of Heidegger and Fink. The seminar was to be conducted over a series of semesters, but since only the Winter Semester in 1966-1967 proved feasible, the current work is in Fink's words "a fragment on the Fragments." The text takes the form of a dialogue between "Heidegger," "Fink," and "Participant," Using the fragments of Heraclitus as (...) a point of departure, the dialogue partners cover a terrain by now familiar to readers of Heidegger: the hermeneutic circle, metaphysics, the "mortals" and the "gods," Hegel's idea of Logic. Heidegger clearly leads the discussion and hence his unique reading of the pre-Socratic philosopher is always the central theme. As Fink says, not the philological problematic, as important as that may be, but rather the attempt to think through the thought of Heraclitus is the issue in this seminar. Fink usually opens the discussion with a preliminary interpretation of Heraclitus in order to provide a common basis for the participants which will be more familiar to them. The volume is frequently punctuated with insights into Heraclitus' text, as anyone who has learned to stay with Heidegger's thoughtful dialogue with classical sources has discovered.--J. D. C. (shrink)

This collection opens with an inquiry into the assumptions and methods of the historical study of culture, comparing the new cultural history with the old. Thirteen essays follow, each defining a problem within a particular culture. In the first section, Biography and Autobiography, three scholars explore historically changing types of self-conception, each reflecting larger cultural meanings; essays included examine Italian Renaissance biographers and the autobiographies of Benjamin Franklin and Mohandas Gandhi. A second group of contributors explore problems raised by the (...) writing of history itself, especially as it relates to a notion of culture. Here examples are drawn from the writings of Thucydides, Jacob Burckhardt, and the art historians Alois Riegl and Josef Strzygowski. In the third section, Politics, Nationalism, and Culture, the essays explore relationships between cultural creativity and national identity, with case studies focusing on the Holy Roman Emperor Maximilian I, the place of Castile within the national history of Spain, and the impact of World War I on work of Thomas Mann. The final section, Cultural Translation, raises the complex questions of cultural influence and the transmission of traditions over time through studies of Philo of Alexandria's interpretation of the Hebrew Bible, Erasmus' use of Socrates, Jean Bodin's conception of Roman law, and adaptations of the Hebrew Bible for American children. (shrink)

La pensée de Eugen Fink s’est formée sous la double influence de Husserl et de Heidegger, mais c’est dans l’œuvre de ce dernier qu’il a trouvé les prémisses de la problématique originale qu’il a développée par la suite, celle d’une phénoménologie cosmologique post-métaphysique dont le modèle opératoire est le jeu. Or c’est chez Nietzsche, auquel il consacre en 1960 un long essai, qu’il retrouve la conjonction de ces deux phénomènes, le monde et le jeu. Il entreprend ainsi de montrer (...) que, contrairement à ce qu’affirme Heidegger, la philosophie de Nietzsche, dans la mesure où il a été capable de penser l’être et le devenir comme jeu, ne fait plus partie de la métaphysique moderne de la subjectivité. (shrink)

Actes d’un colloque qui s’est tenu à Copenhague en 2007, l’ouvrage veut combler un manque : traiter du développement de la dialectique de Platon à Aristote, non pas en se focalisant sur la méthode et l’ontologie, mais en se fondant sur le cadre du débat dialectique. Selon J. Fink (p. 2), la dialectique ici signifie d’abord et avant tout argumentation adressée à un interlocuteur. La pratique de l’argumentation dialectique et son extension dans la forme littéraire du dialogue constituent le (...) cœu... (shrink)

Existenz und Coexistenz č l'opera in cui Eugen Fink espone la sua filosofia sociale in base ai presupposti dell'ontologia del "Mondo" che egli sviluppa a partire dal secondo dopoguerra. Cosě come questa ontologia si compone di piani di analisi differenti, anche la struttura della socialitÀ si rivela complessa e stratificata, tesa fra la descrizione fenomenologica e l'approfondimento speculativo. L'obiettivo del saggio č di esaminare tanto le premesse metodiche e teoriche dell'indagine finkiana, quanto le sue componenti strutturali, al fine di (...) ricostruire la risposta fornita dal pensatore alla questione della coesistenza, nonché la sua originale definizione del rapporto fra individuo e comunitÀ. (shrink)

Eugen Fink is considered one of the clearest interpreters of phenomenology and was the preferred conversational partner of Edmund Husserl and Martin Heidegger. In Play as Symbol of the World, Fink offers an original phenomenology of play as he attempts to understand the world through the experience of play. He affirms the philosophical significance of play, why it is more than idle amusement, and reflects on the movement from "child's play" to "cosmic play." Well-known for its non-technical, literary (...) style, this skillful translation by Ian Alexander Moore and Christopher Turner invites engagement with Fink's philosophy of play and related writings on sports, festivals, and ancient cult practices. (shrink)

The world is experiencing a cataclysmically increasing burden from chronic illnesses. Chronic diseases are on the advance worldwide and treatment strategies to counter this development are dominated by symptom control and polypharmacy. Thus, chronic conditions are often considered irreversible, implying a slow progression of disease that can only be hampered but not stopped. The current plant-based movement is attempting to alter this way of thinking. Applying a nutrition-first approach, the ultimate goal is either disease remission or reversal. Hereby, ethical questions (...) arise as to whether physicians’ current understanding of chronic illness is outdated and morally reprehensible. In this case, physicians may need to recommend plant-based diets to every patient suffering from chronic conditions, while determining what other socioecological factors and environmental aspects play a role in the chronic disease process. This article provides insights to aspects of diet and chronic illness and discusses how the plant-based movement could redefine current understanding of chronic disease. The ethical justifications for recommending of a plant-based diet are analyzed. The article concludes that not advocating for plant-based nutrition is unethical and harms the planet and patients alike. (shrink)

Even if we know all relevant descriptive facts about an act, we can still be uncertain about its moral acceptability. Most literature on how to act under such normative uncertainty operates on moral realism, the metaethical view that there are objective moral facts. Lay people largely report anti-realist intuitions, which poses the question of how these intuitions affect their interpretation and handling of normative uncertainty. Results from two quasi-experimental studies (total N = 365) revealed that most people did not interpret (...) normative uncertainty as referring to objective moral facts but rather as uncertainty regarding one’s own view, uncertainty regarding the culturally accepted view or as the result of ambivalence. Especially the anti-realist majority of participants interpreted normative uncertainty different to how it is described in the literature on choice under normative uncertainty. Metaethical views were also associated with lay peoples’ choice of uncertainty reduction strategies and with assumptions about the intended aim of such strategies. The current findings suggest that empirical investigations of normative uncertainty might benefit from considering folk metaethical pluralism, as the lay public largely disagrees with the metaethical assumptions underlying the current discourse on choice under normative uncertainty. (shrink)